Page 1 of 1

Wood Smoke and COPD

PostPosted: Mon Jun 30, 2014 8:01 pm
by Wilberforce
PDF DL
Wood Smoke and COPD
FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure
http://respiratory-research.com/content ... -15-74.pdf
Abstract
Background
Matrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic
obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to
determine plasma concentrations of MMPs and CRP in COPD associated to biomass
combustion exposure (BE) and tobacco smoking (TS).

Methods
Pulmonary function tests, plasma levels of MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and
CRP were measured in COPD associated to BE (n = 40) and TS (n =40) patients, and healthy
non-smoking (NS) healthy women (controls, n = 40).

Results
Plasma levels of MMP-1, MMP-7, MMP-9, and MMP-9/TIMP-1 and CRP were higher in BE
and TS than in the NS healthy women (p <0.01). An inverse correlation between MMP-1,
MMP-7, MMP-9, MMP-9/TIMP-1 and CRP plasma concentrations and FEV1 was observed.

Conclusions
Increase of MMPs and CRP plasma concentrations in BE suggests a systemic inflammatory
phenomenon similar to that observed in COPD associated to tobacco smoking, which may
also play a role in COPD pathogenesis