Wood Smoke Exposure Alters Human Inflammatory Responses

Research studies on wood smoke and other air pollution.

Wood Smoke Exposure Alters Human Inflammatory Responses

Postby Wilberforce » Thu Dec 27, 2018 3:14 pm

Wood Smoke Exposure Alters Human Inflammatory Responses to Viral Infection in a Sex-Specific Manner: A Randomized, Placebo-Controlled Study
Meghan E Rebuli , Adam M Speen , Elizabeth M Martin ; Kezia A Addo , Erica A Pawlak , Ellen Glista-Baker , Carole Robinette , Haibo Zhou , Terry L. Noah ; ; Ilona Jaspers ; ;

https://doi.org/10.1164/rccm.201807-1287OC PubMed: 30360637
Received: July 13, 2018
Accepted: October 26, 2018
Published Online: October 26, 2018

Rationale: Exposure to particulates from burning biomass is an increasing global health issue. Burning biomass, including wood smoke, is associated with increased lower respiratory infections. Objectives: To determine whether acute exposure to wood smoke modifies nasal inflammatory responses to influenza. Methods: Healthy young adults (N=39) were randomized to a 2-hr controlled chamber exposure to wood smoke, where exposure levels were controlled to particulate number, (WSP) (500 µg/cm3), or filtered air (FA), followed by nasal inoculation with a vaccine dose of live attenuated influenza virus (LAIV). Nasal lavage was performed on pre-exposure (day 0) and days 1 and 2 post-exposure. Nasal lavage fluid cells were analyzed for inflammatory gene expression profiles and cell-free fluid was assayed for cytokines. Measurements and Main Results: Only IP-10 protein levels were affected, suppressed, by WSP exposure in aggregate analysis. Subsequent analysis indicated an exposure*sex interaction, prompting additional analyses of WSP- and LAIV-induced changes in males and females. Inflammation-related gene expression profiles differed between the sexes, at baseline (males greater than females), after LAIV inoculation (females greater than males), and after WSP exposure (increase in males and decrease in females), demonstrating that WSP-and LAIV-induced changes in antiviral defense responses in the nasal mucosa occur in a sex-specific manner. Conclusions: WSP exposure resulted in minimal modification of LAIV-induced responses in aggregate analysis. In contrast, analyzing WSP-induced modification of LAIV responses in the sexes separately unmasked sex-specific differences in response to exposure. These data highlight the need for additional studies to understand sex-specific pollutant-induced effects. Clinical trial registration available at http://www.clinicaltrials.gov, ID NCT02183753.
• The Surgeon General has determined that there is no safe level of exposure to ambient smoke!

• If you smell even a subtle odor of smoke, you are being exposed to poisonous and carcinogenic chemical compounds!

• Even a brief exposure to smoke raises blood pressure, (no matter what your state of health) and can cause blood clotting, stroke, or heart attack in vulnerable people. Even children experience elevated blood pressure when exposed to smoke!

• Since smoke drastically weakens the lungs' immune system, avoiding smoke is one of the best ways to prevent colds, flu, bronchitis, or risk of an even more serious respiratory illness, such as pneumonia or tuberculosis! Does your child have the flu? Chances are they have been exposed to ambient smoke!
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