Activation of TRPA1 in Lung Cells by Wood Smoke

Research studies on wood smoke and other air pollution.

Activation of TRPA1 in Lung Cells by Wood Smoke

Postby Wilberforce » Fri Mar 29, 2013 6:31 pm

Activation of Transient Receptor Potential Ankyrin-1 (TRPA1) in Lung Cells by Wood Smoke Particulate Material
by Darien Shapiro
http://content.lib.utah.edu/utils/getfi ... e/2404.pdf
Exposure to ambient cdPM, especially WSPM, is increasingly being recognized as a cause of many adverse health effects in humans. Many studies have reported increased hospitalization rates due to exacerbation of pre-existing diseases such as asthma, and increased rates of chronic bronchitis, respiratory infection, chronic obstructive pulmonary disease (COPD), and premature death when investigating the effects of PM on human health (Laumbach & Kipen, 2012; Naeher et al., 2007; Noonan, Ward, Navidi, & Sheppard, 2012; Schei et al., 2004). This work identifies TRPA1 as a selective molecular sensor for WSPM in lung cells, which are representative of human airway sensory neurons and cells that express TRPA1.
Therefore, TRPA1 may have an important role in the control of respiratory responses to WSPM exposure, and it may be possible to develop therapeutic targets for TRPA1 to protect individuals who are at high risk for developing adverse health effects (e.g., asthmatics, children, elderly) when exposed to WSPM and r lated cdPM.
• The Surgeon General has determined that there is no safe level of exposure to ambient smoke!

• If you smell even a subtle odor of smoke, you are being exposed to poisonous and carcinogenic chemical compounds!

• Even a brief exposure to smoke raises blood pressure, (no matter what your state of health) and can cause blood clotting, stroke, or heart attack in vulnerable people. Even children experience elevated blood pressure when exposed to smoke!

• Since smoke drastically weakens the lungs' immune system, avoiding smoke is one of the best ways to prevent colds, flu, bronchitis, or risk of an even more serious respiratory illness, such as pneumonia or tuberculosis! Does your child have the flu? Chances are they have been exposed to ambient smoke!
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