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Fine Particulate Air Pollution and Atherosclerosis

PostPosted: Tue Apr 23, 2013 9:53 pm
by Wilberforce
Fine Particulate Air Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study from the Multi-Ethnic Study of Atherosclerosis and Air Pollution
Adar, et al
These findings suggest that higher long-term PM2.5 concentrations are associated with increased IMT progression—a surrogate for atherosclerosis progression—and that larger reductions in PM2.5 are associated with slower IMT progression. By combining these findings with other results from MESA Air, the researchers estimate that individuals living in parts of town with 2.5 µg/m3 higher PM2.5 levels may have a 2% increased risk of stroke compared to people living in less polluted regions of the same metropolitan area. Because of study limitations such as the use of a surrogate marker for atherosclerosis and the failure to account for changes in other factors that might also have affected CVD risk, the findings reported here should be interpreted cautiously. Nevertheless, these findings support the hypothesis that long-term exposure to PM2.5 is associated with the progression of atherosclerosis and consequently with an increased risk of CVD, even at PM2.5 levels below existing regulatory standards.