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Ambient Fine Particulate Air Pollution and Lung Cancer

PostPosted: Mon Aug 15, 2016 5:45 pm
by Wilberforce
http://ehp.niehs.nih.gov/ehp124/
The Association between Ambient Fine Particulate Air Pollution and Lung Cancer Incidence: Results from the AHSMOG-2 Study
Lida Gharibvand,1 David Shavlik,2 Mark Ghamsary,3 W. Lawrence Beeson,1,2 Samuel Soret,3 Raymond Knutsen,1,2 and Synnove F. Knutsen1,2

Background: There is a positive association between ambient fine particulate matter (PM2.5) and incidence and mortality of lung cancer (LC), but few studies have assessed the relationship between ambient PM2.5 and LC among never smokers.

Objectives: To assess the association between PM2.5 and risk of LC using the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of health conscious non-smokers where 81% have never smoked.

Methods: A total of 80,285 AHSMOG-2 subjects were followed for an average of 7.5 years with respect to incident LC identified through linkage with U.S. state cancer registries. Estimates of ambient air pollution levels at subjects’ residences were obtained for 2000 and 2001, the years immediately prior to study start.

Results: A total of 250 incident LC cases occurred during 598,927 person-years of follow-up. For each 10-µg/m3 increment in PM2.5, adjusted hazard ratio (HR) with 95% confidence interval (CI) for LC incidence was 1.43 (95% CI: 1.11, 1.84) in the two-pollutant multivariable model with O3. Among those who spent more than 1 hr/day outdoors or who had lived 5 or more years at their enrollment address, the HR was 1.68 (95% CI: 1.28, 2.22) and 1.54 (95% CI: 1.17, 2.04), respectively.

Conclusion: Increased risk estimates of LC were observed for each 10-µg/m3 increment in ambient PM2.5 concentration. The estimate was higher among those with longer residence at enrollment address and those who spent more than 1 hr/day outdoors.