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Biomass fuel smoke exposure ...adverse cardiac remodeling

PostPosted: Wed Dec 21, 2016 8:04 pm
by Wilberforce
RESEARCH PPV

http://onlinelibrary.wiley.com/doi/10.1 ... 2/abstract

Biomass fuel smoke exposure was associated with adverse cardiac remodeling and left ventricular dysfunction in Peru
Burroughs-Pena, et al

Accepted manuscript online: 19 December 2016
DOI: 10.1111/ina.12362

Abstract

Background
While household air pollution from biomass fuel combustion has been linked to cardiovascular disease, the effects on cardiac structure and function have not been well described. We sought to determine the association between biomass fuel smoke exposure and cardiac structure and function by transthoracic echocardiography.

Methods
We identified a random sample of urban and rural residents living in the high-altitude region of Puno, Peru. Daily biomass fuel use was self-reported. Participants underwent transthoracic echocardiography. Multivariable linear regression was used to examine the relationship of biomass fuel use with echocardiographic measures of cardiac structure and function, adjusting for age, sex, height, body mass index, diabetes, physical activity, and tobacco use.

Results
187 participants (80 biomass fuel users and 107 nonusers) were included in this analysis (mean age 59 years, 58% women). After adjustment, daily exposure to biomass fuel smoke was associated with increased left ventricular internal diastolic diameter (p=0.004), left atrial diameter (p=0.03), left atrial area 4-chamber (p=0.004) and 2-chamber (p=0.03), septal E’ (p=0.006), and lateral E’ (p=0.04). Exposure to biomass fuel smoke was also associated with worse global longitudinal strain in the 2-chamber view (p=0.01).

Conclusion
Daily biomass fuel use was associated with increased left ventricular size and decreased left ventricular systolic function by global longitudinal strain.