Respiratory Tract Inflammation and Mucous Cell Hyperplasia
from Repeated Exposure to Wood Smoke
Principal Investigator: Johannes Tesfaigzi
Co-Investigators: Edward B. Barr, Carole A.Conn, Fletcher F.Hahn
Wood smoke is a complex, particle-containing mixture that is associated
with a number of respiratory illnesses in humans. It is also an
important seasonal environmental air contaminant in several locations
in the U.S. There is a very small toxicological database on subchronic,
repeated exposures to wood smoke, and less on chronic toxicity.
This study will evaluate the inhalation toxicity of smoke from
a wood stove in rats exposed for 90 days. The wood and stove were
selected to simulate exposures of a specific New Mexico Native
American population in which a high incidence of childhood asthma
may be associated with wood fuel use. The exposure levels are
based on measurements in homes (highest level 2000 ~g/m3). The
exposure atmosphere will be characterized in detail. Dr. Glen
Cass, California Institute of Technology, will assist with detailed
chemical analyses of particulate material. Biological endpoints
will include respiratory function, airway and lung inflammation,
mucous hyperplasia, and immune responses. This study serves as
a pilot project to explore wood smoke exposure methodology and
selection of biological responses for planning future Center research
involving wood smoke.
©1998 by Lovelace Respiratory Research Institute
PO Box 5890, Albuquerque, New Mexico USA 87185-5890
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